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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTGIS (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5740
Official gene symbolPTGIS
Full nameprostaglandin I2 (prostacyclin) synthase
Aliases,CYP8,CYP8A1,MGC126858,MGC126860,PGIS,PTGI,
Gene summaryThis gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq]
LocationChromosome: 20   Locus: 20q13.13
Gene position48184707 - 48120411  Map Viewer
Gene orientationminus
Gene size64297 bp
Gene sequence
OMIM ID601699