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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTGS1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5742
Official gene symbolPTGS1
Full nameprostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
Aliases,COX1,COX3,PCOX1,PGG/HS,PGHS-1,PGHS1,PHS1,PTGHS,
Gene summaryProstaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis. Alternative splicing of this gene generates two transcript variants. The expression of these two transcripts is differentially regulated by relevant cytokines and growth factors. [provided by RefSeq]
LocationChromosome: 9   Locus: 9q32-q33.3
Gene position125133229 - 125157981  Map Viewer
Gene orientationplus
Gene size24753 bp
Gene sequence
OMIM ID176805