Entrez gene ID | | 5743 |
Official gene symbol | | PTGS2 |
Full name | | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) |
Aliases | | ,COX-2,COX2,GRIPGHS,PGG/HS,PGHS-2,PHS-2,hCox-2, |
Gene summary | | Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q25.2-q25.3 |
Gene position | | 186649559 - 186640944 Map Viewer |
Gene orientation | | minus |
Gene size | | 8616 bp |
Gene sequence |
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OMIM ID | | 600262 |
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