Entrez gene ID | | 57591 |
Official gene symbol | | MKL1 |
Full name | | megakaryoblastic leukemia (translocation) 1 |
Aliases | | ,BSAC,MAL,MRTF-A, |
Gene summary | | The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia. [provided by RefSeq] |
Location | | Chromosome: 22 Locus: 22q13 |
Gene position | | 41032690 - 40806292 Map Viewer |
Gene orientation | | minus |
Gene size | | 226399 bp |
Gene sequence |
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OMIM ID | | 606078 |
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