Entrez gene ID | | 57680 |
Official gene symbol | | CHD8 |
Full name | | chromodomain helicase DNA binding protein 8 |
Aliases | | ,DKFZp686N17164,HELSNF1,KIAA1564, |
Gene summary | | This gene encodes a DNA helicase that functions as a transcription repressor by remodeling chromatin structure. It binds beta-catenin and negatively regulates Wnt signaling pathway, which plays a pivotal role in vertebrate early development and morphogenesis. Mice lacking this gene exhibit early embryonic death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 14 Locus: 14q11.2 |
Gene position | | 21905457 - 21853353 Map Viewer |
Gene orientation | | minus |
Gene size | | 52105 bp |
Gene sequence |
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OMIM ID | | 610528 |