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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PTPN6 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5777
Official gene symbolPTPN6
Full nameprotein tyrosine phosphatase, non-receptor type 6
Aliases,HCP,HCPH,HPTP1C,PTP-1C,SH-PTP1,SHP-1,SHP-1L,SHP1,
Gene summaryThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq]
LocationChromosome: 12   Locus: 12p13
Gene position7055740 - 7070479  Map Viewer
Gene orientationplus
Gene size14740 bp
Gene sequence
OMIM ID176883