Database of mammalian genes
Home

Home Search Browse RAGs User guide FAQs Links Questions Contribute

Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ZP4 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID57829
Official gene symbolZP4
Full namezona pellucida glycoprotein 4
Aliases,ZBP,ZP1,ZPB,Zp-4,
Gene summaryThe zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. Previously, this gene has been referred to as ZP1 or ZPB and thought to have similar functions as mouse Zp1. However, a human gene with higher similarity and chromosomal synteny to mouse Zp1 has been assigned the symbol ZP1 and this gene has been assigned the symbol ZP4. [provided by RefSeq]
LocationChromosome: 1   Locus: 1q43
Gene position238054222 - 238041164  Map Viewer
Gene orientationminus
Gene size13059 bp
Gene sequence
OMIM ID613514