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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for WFDC1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID58189
Official gene symbolWFDC1
Full nameWAP four-disulfide core domain 1
Aliases,PS20,
Gene summaryThis gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. The encoded protein shares 81% amino acid identity with the rat ps20 protein, which was originally identified as a secreted growth inhibitor. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. Owing to its location and a possible growth inhibitory property of its gene product, this gene is suggested to be a tumor suppressor gene. [provided by RefSeq]
LocationChromosome: 16   Locus: 16q24.3
Gene position84328401 - 84363450  Map Viewer
Gene orientationplus
Gene size35050 bp
Gene sequence
OMIM ID605322