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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RAD17 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5884
Official gene symbolRAD17
Full nameRAD17 homolog (S. pombe)
Aliases,CCYC,FLJ41520,HRAD17,R24L,RAD17SP,RAD24,
Gene summaryThe protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq]
LocationChromosome: 5   Locus: 5q13
Gene position68665124 - 68710628  Map Viewer
Gene orientationplus
Gene size45505 bp
Gene sequence
OMIM ID603139