Entrez gene ID | | 5884 |
Official gene symbol | | RAD17 |
Full name | | RAD17 homolog (S. pombe) |
Aliases | | ,CCYC,FLJ41520,HRAD17,R24L,RAD17SP,RAD24, |
Gene summary | | The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q13 |
Gene position | | 68665124 - 68710628 Map Viewer |
Gene orientation | | plus |
Gene size | | 45505 bp |
Gene sequence |
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OMIM ID | | 603139 |
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