Entrez gene ID | | 5902 |
Official gene symbol | | RANBP1 |
Full name | | RAN binding protein 1 |
Aliases | | ,HTF9A,MGC88701, |
Gene summary | | Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RanGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN. [provided by RefSeq] |
Location | | Chromosome: 22 Locus: 22q11.21 |
Gene position | | 20105024 - 20114704 Map Viewer |
Gene orientation | | plus |
Gene size | | 9681 bp |
Gene sequence |
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OMIM ID | | 601180 |
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