Entrez gene ID | | 5905 |
Official gene symbol | | RANGAP1 |
Full name | | Ran GTPase activating protein 1 |
Aliases | | ,Fug1,KIAA1835,MGC20266,SD, |
Gene summary | | RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq] |
Location | | Chromosome: 22 Locus: 22q13 |
Gene position | | 41682216 - 41641615 Map Viewer |
Gene orientation | | minus |
Gene size | | 40602 bp |
Gene sequence |
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OMIM ID | | 602362 |
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