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Gene information for RANGAP1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5905
Official gene symbolRANGAP1
Full nameRan GTPase activating protein 1
Aliases,Fug1,KIAA1835,MGC20266,SD,
Gene summaryRanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. [provided by RefSeq]
LocationChromosome: 22   Locus: 22q13
Gene position41682216 - 41641615  Map Viewer
Gene orientationminus
Gene size40602 bp
Gene sequence
OMIM ID602362