Entrez gene ID | | 5932 |
Official gene symbol | | RBBP8 |
Full name | | retinoblastoma binding protein 8 |
Aliases | | ,CTIP,RIM, |
Gene summary | | The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq] |
Location | | Chromosome: 18 Locus: 18q11.2 |
Gene position | | 20513295 - 20606449 Map Viewer |
Gene orientation | | plus |
Gene size | | 93155 bp |
Gene sequence |
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OMIM ID | | 604124 |
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