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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for RET (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID5979
Official gene symbolRET
Full nameret proto-oncogene
Aliases,CDHF12,CDHR16,HSCR1,MEN2A,MEN2B,MTC1,PTC,RET-ELE1,RET51,
Gene summaryThis gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. [provided by RefSeq]
LocationChromosome: 10   Locus: 10q11.2
Gene position43572517 - 43625799  Map Viewer
Gene orientationplus
Gene size53283 bp
Gene sequence
OMIM ID164761