Entrez gene ID | | 5999 |
Official gene symbol | | RGS4 |
Full name | | regulator of G-protein signaling 4 |
Aliases | | ,DKFZp761F1924,MGC2124,MGC60244,RGP4,SCZD9, |
Gene summary | | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q23.3 |
Gene position | | 163038396 - 163046592 Map Viewer |
Gene orientation | | plus |
Gene size | | 8197 bp |
Gene sequence |
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OMIM ID | | 602516 |