Entrez gene ID | | 6035 |
Official gene symbol | | RNASE1 |
Full name | | ribonuclease, RNase A family, 1 (pancreatic) |
Aliases | | ,MGC12408,RIB1,RNS1, |
Gene summary | | This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. [provided by RefSeq] |
Location | | Chromosome: 14 Locus: 14q11.2 |
Gene position | | 21271036 - 21269515 Map Viewer |
Gene orientation | | minus |
Gene size | | 1522 bp |
Gene sequence |
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OMIM ID | | 180440 |
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