Entrez gene ID | | 6091 |
Official gene symbol | | ROBO1 |
Full name | | roundabout, axon guidance receptor, homolog 1 (Drosophila) |
Aliases | | ,DUTT1,FLJ21882,MGC131599,MGC133277,SAX3, |
Gene summary | | Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and across the midline in response to long-range chemoattractants emanating from the midline. The product of this gene is a member of the immunoglobulin gene superfamily and encodes an integral membrane protein that functions in axon guidance and neuronal precursor cell migration. This receptor is activated by SLIT-family proteins, resulting in a repulsive effect on glioma cell guidance in the developing brain. A related gene is located at an adjacent region on chromosome 3. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3p12 |
Gene position | | 79817059 - 78646388 Map Viewer |
Gene orientation | | minus |
Gene size | | 1170672 bp |
Gene sequence |
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OMIM ID | | 602430 |