Entrez gene ID | | 6352 |
Official gene symbol | | CCL5 |
Full name | | chemokine (C-C motif) ligand 5 |
Aliases | | ,D17S136E,MGC17164,RANTES,SCYA5,SISd,TCP228, |
Gene summary | | This gene is one of several CC cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17q11.2-q12 |
Gene position | | 34207377 - 34198495 Map Viewer |
Gene orientation | | minus |
Gene size | | 8883 bp |
Gene sequence |
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OMIM ID | | 187011 |