Entrez gene ID | | 64132 |
Official gene symbol | | XYLT2 |
Full name | | xylosyltransferase II |
Aliases | | ,PXYLT2,XT-II,XT2,xylT-II, |
Gene summary | | The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. [provided by RefSeq] |
Location | | Chromosome: 17 Locus: 17q21.3-q22 |
Gene position | | 48423393 - 48438512 Map Viewer |
Gene orientation | | plus |
Gene size | | 15120 bp |
Gene sequence |
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OMIM ID | | 608125 |
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