Entrez gene ID | | 6422 |
Official gene symbol | | SFRP1 |
Full name | | secreted frizzled-related protein 1 |
Aliases | | ,FRP,FRP-1,FRP1,FrzA,SARP2, |
Gene summary | | This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. This gene may also be involved in determining the polarity of photoreceptor cells in the retina. [provided by RefSeq] |
Location | | Chromosome: 8 Locus: 8p12-p11.1 |
Gene position | | 41166990 - 41119476 Map Viewer |
Gene orientation | | minus |
Gene size | | 47515 bp |
Gene sequence |
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OMIM ID | | 604156 |