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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for UPF3A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID65110
Official gene symbolUPF3A
Full nameUPF3 regulator of nonsense transcripts homolog A (yeast)
Aliases,HUPF3A,RENT3A,UPF3,
Gene summaryThis gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 13   Locus: 13q34
Gene position115047078 - 115071283  Map Viewer
Gene orientationplus
Gene size24206 bp
Gene sequence
OMIM ID605530