Entrez gene ID | | 6546 |
Official gene symbol | | SLC8A1 |
Full name | | solute carrier family 8 (sodium/calcium exchanger), member 1 |
Aliases | | ,DKFZp779F0871,FLJ37694,FLJ43417,MGC119581,NCX1, |
Gene summary | | In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM] |
Location | | Chromosome: 2 Locus: 2p23-p22 |
Gene position | | 40739575 - 40339286 Map Viewer |
Gene orientation | | minus |
Gene size | | 400290 bp |
Gene sequence |
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OMIM ID | | 182305 |
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