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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SLC8A1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6546
Official gene symbolSLC8A1
Full namesolute carrier family 8 (sodium/calcium exchanger), member 1
Aliases,DKFZp779F0871,FLJ37694,FLJ43417,MGC119581,NCX1,
Gene summaryIn cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM]
LocationChromosome: 2   Locus: 2p23-p22
Gene position40739575 - 40339286  Map Viewer
Gene orientationminus
Gene size400290 bp
Gene sequence
OMIM ID182305