Entrez gene ID | | 6573 |
Official gene symbol | | SLC19A1 |
Full name | | solute carrier family 19 (folate transporter), member 1 |
Aliases | | ,CHMD,FOLT,IFC1,REFC,RFC1, |
Gene summary | | Transport of folate compounds into mammalian cells can occur via receptor-mediated (see MIM 136430) or carrier-mediated mechanisms. A functional coordination between these 2 mechanisms has been proposed to be the method of folate uptake in certain cell types. Methotrexate (MTX) is an antifolate chemotherapeutic agent that is actively transported by the carrier-mediated uptake system. RFC1 plays a role in maintaining intracellular concentrations of folate.[supplied by OMIM] |
Location | | Chromosome: 21 Locus: 21q22.3 |
Gene position | | 46962351 - 46934629 Map Viewer |
Gene orientation | | minus |
Gene size | | 27723 bp |
Gene sequence |
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OMIM ID | | 600424 |