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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SREBF1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6720
Official gene symbolSREBF1
Full namesterol regulatory element binding transcription factor 1
Aliases,SREBP-1c,SREBP1,bHLHd1,
Gene summaryThis gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 17   Locus: 17p11.2
Gene position17740325 - 17714663  Map Viewer
Gene orientationminus
Gene size25663 bp
Gene sequence
OMIM ID184756