Entrez gene ID | | 673 |
Official gene symbol | | BRAF |
Full name | | v-raf murine sarcoma viral oncogene homolog B1 |
Aliases | | ,B-RAF1,BRAF1,FLJ95109,MGC126806,MGC138284,RAFB1, |
Gene summary | | This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7q34 |
Gene position | | 140624564 - 140433812 Map Viewer |
Gene orientation | | minus |
Gene size | | 190753 bp |
Gene sequence |
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OMIM ID | | 164757 |
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