Entrez gene ID | | 6741 |
Official gene symbol | | SSB |
Full name | | Sjogren syndrome antigen B (autoantigen La) |
Aliases | | ,LARP3,La, |
Gene summary | | La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006 [PubMed 16387655]).[supplied by OMIM] |
Location | | Chromosome: 2 Locus: 2q31.1 |
Gene position | | 170655389 - 170668575 Map Viewer |
Gene orientation | | plus |
Gene size | | 13187 bp |
Gene sequence |
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OMIM ID | | 109090 |
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