Entrez gene ID | | 6768 |
Official gene symbol | | ST14 |
Full name | | suppression of tumorigenicity 14 (colon carcinoma) |
Aliases | | ,HAI,MT-SP1,MTSP1,PRSS14,SNC19,TADG15,TMPRSS14, |
Gene summary | | The protein encoded by this gene is an epithelial-derived, integral membrane serine protease. This protease forms a complex with the Kunitz-type serine protease inhibitor, HAI-1, and is found to be activated by sphingosine 1-phosphate. This protease has been shown to cleave and activate hepatocyte growth factor/scattering factor, and urokinase plasminogen activator, which suggest the function of this protease as an epithelial membrane activator for other proteases and latent growth factors. The expression of this protease has been associated with breast, colon, prostate, and ovarian tumors, which implicates its role in cancer invasion, and metastasis. [provided by RefSeq] |
Location | | Chromosome: 11 Locus: 11q24-q25 |
Gene position | | 130029682 - 130080257 Map Viewer |
Gene orientation | | plus |
Gene size | | 50576 bp |
Gene sequence |
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OMIM ID | | 606797 |
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