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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for STAT5A (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6776
Official gene symbolSTAT5A
Full namesignal transducer and activator of transcription 5A
Aliases,MGF,STAT5,
Gene summaryThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq]
LocationChromosome: 17   Locus: 17q11.2
Gene position40439565 - 40463961  Map Viewer
Gene orientationplus
Gene size24397 bp
Gene sequence
OMIM ID601511