Entrez gene ID | | 6778 |
Official gene symbol | | STAT6 |
Full name | | signal transducer and activator of transcription 6, interleukin-4 induced |
Aliases | | ,D12S1644,IL-4-STAT,STAT6B,STAT6C, |
Gene summary | | The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. |
Location | | Chromosome: 12 Locus: 12q13 |
Gene position | | 57505196 - 57489187 Map Viewer |
Gene orientation | | minus |
Gene size | | 16010 bp |
Gene sequence |
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OMIM ID | | 601512 |
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