Entrez gene ID | | 6786 |
Official gene symbol | | STIM1 |
Full name | | stromal interaction molecule 1 |
Aliases | | ,D11S4896E,GOK, |
Gene summary | | This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. |
Location | | Chromosome: 11 Locus: 11p15.5 |
Gene position | | 3876933 - 4114440 Map Viewer |
Gene orientation | | plus |
Gene size | | 237508 bp |
Gene sequence |
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OMIM ID | | 605921 |
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