Entrez gene ID | | 6840 |
Official gene symbol | | SVIL |
Full name | | supervillin |
Aliases | | ,DKFZp686A17191, |
Gene summary | | This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq] |
Location | | Chromosome: 10 Locus: 10p11.2 |
Gene position | | 30024730 - 29746277 Map Viewer |
Gene orientation | | minus |
Gene size | | 278454 bp |
Gene sequence |
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OMIM ID | | 604126 |
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