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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for SVIL (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6840
Official gene symbolSVIL
Full namesupervillin
Aliases,DKFZp686A17191,
Gene summaryThis gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq]
LocationChromosome: 10   Locus: 10p11.2
Gene position30024730 - 29746277  Map Viewer
Gene orientationminus
Gene size278454 bp
Gene sequence
OMIM ID604126