Entrez gene ID | | 6924 |
Official gene symbol | | TCEB3 |
Full name | | transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) |
Aliases | | ,EloA,FLJ38760,FLJ42849,SIII,SIII p110,TCEB3A, |
Gene summary | | This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1p36.1 |
Gene position | | 24069856 - 24088549 Map Viewer |
Gene orientation | | plus |
Gene size | | 18694 bp |
Gene sequence |
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OMIM ID | | 600786 |
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