Entrez gene ID | | 6928 |
Official gene symbol | | HNF1B |
Full name | | HNF1 homeobox B |
Aliases | | ,FJHN,HNF1beta,HNF2,HPC11,LF-B3,LFB3,MODY5,TCF2,VHNF1, |
Gene summary | | This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene. |
Location | | Chromosome: 17 Locus: 17cen-q21.3 |
Gene position | | 36105096 - 36046434 Map Viewer |
Gene orientation | | minus |
Gene size | | 58663 bp |
Gene sequence |
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OMIM ID | | 189907 |
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