Entrez gene ID | | 6996 |
Official gene symbol | | TDG |
Full name | | thymine-DNA glycosylase |
Aliases | | ,-, |
Gene summary | | The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q24.1 |
Gene position | | 104359593 - 104382656 Map Viewer |
Gene orientation | | plus |
Gene size | | 23064 bp |
Gene sequence |
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