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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TDG (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID6996
Official gene symbolTDG
Full namethymine-DNA glycosylase
Aliases,-,
Gene summaryThe protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq]
LocationChromosome: 12   Locus: 12q24.1
Gene position104359593 - 104382656  Map Viewer
Gene orientationplus
Gene size23064 bp
Gene sequence