Entrez gene ID | | 7010 |
Official gene symbol | | TEK |
Full name | | TEK tyrosine kinase, endothelial |
Aliases | | ,CD202B,TIE-2,TIE2,VMCM,VMCM1, |
Gene summary | | The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq] |
Location | | Chromosome: 9 Locus: 9p21 |
Gene position | | 27109147 - 27230172 Map Viewer |
Gene orientation | | plus |
Gene size | | 121026 bp |
Gene sequence |
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OMIM ID | | 600221 |