Entrez gene ID | | 7130 |
Official gene symbol | | TNFAIP6 |
Full name | | tumor necrosis factor, alpha-induced protein 6 |
Aliases | | ,TSG-6,TSG6, |
Gene summary | | The protein encoded by this gene is a secretory protein that contains a hyaluronan-binding domain, and thus is a member of the hyaluronan-binding protein family. The hyaluronan-binding domain is known to be involved in extracellular matrix stability and cell migration. This protein has been shown to form a stable complex with inter-alpha-inhibitor (I alpha I), and thus enhance the serine protease inhibitory activity of I alpha I, which is important in the protease network associated with inflammation. The expression of this gene can be induced by tumor necrosis factor alpha and interleukin-1. The expression can also be induced by mechanical stimuli in vascular smooth muscle cells, and is found to be correlated with proteoglycan synthesis and aggregation. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2q23.3 |
Gene position | | 152214105 - 152236560 Map Viewer |
Gene orientation | | plus |
Gene size | | 22456 bp |
Gene sequence |
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OMIM ID | | 600410 |
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