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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TRAF2 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7186
Official gene symbolTRAF2
Full nameTNF receptor-associated factor 2
Aliases,MGC:45012,TRAP,TRAP3,
Gene summaryThe protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq]
LocationChromosome: 9   Locus: 9q34
Gene position139780965 - 139821067  Map Viewer
Gene orientationplus
Gene size40103 bp
Gene sequence
OMIM ID601895