Entrez gene ID | | 7292 |
Official gene symbol | | TNFSF4 |
Full name | | tumor necrosis factor (ligand) superfamily, member 4 |
Aliases | | ,CD134L,CD252,GP34,OX-40L,OX4OL,TXGP1, |
Gene summary | | The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF4/OX4. It is found to be involved in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells. [provided by RefSeq] |
Location | | Chromosome: 1 Locus: 1q25 |
Gene position | | 173176471 - 173152870 Map Viewer |
Gene orientation | | minus |
Gene size | | 23602 bp |
Gene sequence |
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OMIM ID | | 603594 |