Entrez gene ID | | 729230 |
Official gene symbol | | CCR2 |
Full name | | chemokine (C-C motif) receptor 2 |
Aliases | | ,CC-CKR-2,CCR2A,CCR2B,CD192,CKR2,CKR2A,CKR2B,CMKBR2,FLJ78302,MCP-1-R,MGC103828,MGC111760,MGC168006, |
Gene summary | | This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq] |
Location | | Chromosome: 3 Locus: 3p21.31 |
Gene position | | 46395235 - 46402413 Map Viewer |
Gene orientation | | plus |
Gene size | | 7179 bp |
Gene sequence |
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OMIM ID | | 601267 |
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