Entrez gene ID | | 7296 |
Official gene symbol | | TXNRD1 |
Full name | | thioredoxin reductase 1 |
Aliases | | ,GRIM-12,MGC9145,TR,TR1,TRXR1,TXNR, |
Gene summary | | This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq] |
Location | | Chromosome: 12 Locus: 12q23-q24.1 |
Gene position | | 104609559 - 104744062 Map Viewer |
Gene orientation | | plus |
Gene size | | 134504 bp |
Gene sequence |
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OMIM ID | | 601112 |
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