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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for TXNRD1 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7296
Official gene symbolTXNRD1
Full namethioredoxin reductase 1
Aliases,GRIM-12,MGC9145,TR,TR1,TRXR1,TXNR,
Gene summaryThis gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq]
LocationChromosome: 12   Locus: 12q23-q24.1
Gene position104609559 - 104744062  Map Viewer
Gene orientationplus
Gene size134504 bp
Gene sequence
OMIM ID601112