Entrez gene ID | | 7298 |
Official gene symbol | | TYMS |
Full name | | thymidylate synthetase |
Aliases | | ,HST422,MGC88736,TMS,TS, |
Gene summary | | Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq] |
Location | | Chromosome: 18 Locus: 18p11.32 |
Gene position | | 657604 - 673499 Map Viewer |
Gene orientation | | plus |
Gene size | | 15896 bp |
Gene sequence |
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OMIM ID | | 188350 |
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