Entrez gene ID | | 7320 |
Official gene symbol | | UBE2B |
Full name | | ubiquitin-conjugating enzyme E2B (RAD6 homolog) |
Aliases | | ,E2-17kDa,HHR6B,HR6B,RAD6B,UBC2, |
Gene summary | | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [provided by RefSeq] |
Location | | Chromosome: 5 Locus: 5q23-q31 |
Gene position | | 133706870 - 133727799 Map Viewer |
Gene orientation | | plus |
Gene size | | 20930 bp |
Gene sequence |
| |
OMIM ID | | 179095 |
|