Entrez gene ID | | 7332 |
Official gene symbol | | UBE2L3 |
Full name | | ubiquitin-conjugating enzyme E2L 3 |
Aliases | | ,E2-F1,L-UBC,UBCH7,UbcM4, |
Gene summary | | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq] |
Location | | Chromosome: 22 Locus: 22q11.21 |
Gene position | | 21921957 - 21978323 Map Viewer |
Gene orientation | | plus |
Gene size | | 56367 bp |
Gene sequence |
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OMIM ID | | 603721 |