Entrez gene ID | | 7343 |
Official gene symbol | | UBTF |
Full name | | upstream binding transcription factor, RNA polymerase I |
Aliases | | ,NOR-90,UBF, |
Gene summary | | Upstream binding factor (UBF) is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and multiple TBP-associated factors or 'TAFs'). Two UBF polypeptides, of 94 and 97 kD, exist in the human (Bell et al., 1988 [PubMed 3413483]). UBF is a nucleolar phosphoprotein with both DNA binding and transactivation domains. Sequence-specific DNA binding to the core and upstream control elements of the human rRNA promoter is mediated through several HMG boxes (Jantzen et al., 1990 [PubMed 2330041]).[supplied by OMIM] |
Location | | Chromosome: 17 Locus: 17q21.3 |
Gene position | | 42298250 - 42282401 Map Viewer |
Gene orientation | | minus |
Gene size | | 15850 bp |
Gene sequence |
| |
OMIM ID | | 600673 |
|