Entrez gene ID | | 7517 |
Official gene symbol | | XRCC3 |
Full name | | X-ray repair complementing defective repair in Chinese hamster cells 3 |
Aliases | | ,-, |
Gene summary | | This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq] |
Location | | Chromosome: 14 Locus: 14q32.3 |
Gene position | | 104181823 - 104163954 Map Viewer |
Gene orientation | | minus |
Gene size | | 17870 bp |
Gene sequence |
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OMIM ID | | 600675 |