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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for ZAP70 (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7535
Official gene symbolZAP70
Full namezeta-chain (TCR) associated protein kinase 70kDa
Aliases,FLJ17670,FLJ17679,SRK,STD,TZK,ZAP-70,
Gene summaryThis gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq]
LocationChromosome: 2   Locus: 2q12
Gene position98330031 - 98356323  Map Viewer
Gene orientationplus
Gene size26293 bp
Gene sequence
OMIM ID176947