Entrez gene ID | | 7783 |
Official gene symbol | | ZP2 |
Full name | | zona pellucida glycoprotein 2 (sperm receptor) |
Aliases | | ,ZPA,Zp-2, |
Gene summary | | The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. [provided by RefSeq] |
Location | | Chromosome: 16 Locus: 16p12 |
Gene position | | 21222868 - 21208773 Map Viewer |
Gene orientation | | minus |
Gene size | | 14096 bp |
Gene sequence |
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OMIM ID | | 182888 |
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