| Entrez gene ID | | 780 |
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| Official gene symbol | | DDR1 |
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| Full name | | discoidin domain receptor tyrosine kinase 1 |
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| Aliases | | ,CAK,CD167,DDR,EDDR1,HGK2,MCK10,NEP,NTRK4,PTK3,PTK3A,RTK6,TRKE, |
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| Gene summary | | Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly over-expressed in several human tumors from breast, ovarian, esophageal, and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq] |
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| Location | | Chromosome: 6 Locus: 6p21.3 |
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| Gene position | | 30851861 - 30867933 Map Viewer |
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| Gene orientation | | plus |
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| Gene size | | 16073 bp |
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| Gene sequence |
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| OMIM ID | | 600408 |
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