Entrez gene ID | | 7837 |
Official gene symbol | | PXDN |
Full name | | peroxidasin homolog (Drosophila) |
Aliases | | ,D2S448,D2S448E,KIAA0230,MG50,PRG2,PXN,VPO, |
Gene summary | | Drosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999 [PubMed 10441517]). It is expressed exclusively in hemocytes derived from head mesoderm at a very early stage of differentiation. Peroxidasin exists as a homotrimer with a unique hybrid structure that combines an enzymatically functional peroxidase domain with motifs that are typically found in extracellular matrix-associated proteins. It is a secreted protein that contains a secretory recognition sequence at its N terminus. Peroxidasin catalyzes hydrogen peroxide-driven radioiodination, oxidations, and the formation of dityrosine in vitro. It is also thought to function in extracellular matrix consolidation, phagocytosis, and defense.[supplied by OMIM] |
Location | | Chromosome: 2 Locus: 2p25 |
Gene position | | 1748291 - 1635659 Map Viewer |
Gene orientation | | minus |
Gene size | | 112633 bp |
Gene sequence |
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OMIM ID | | 605158 |
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