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Gene Protein Transcript Promoter Expression GO/PPI PubMed Cross reference

Gene information for PXDN (Homo sapiens)
(Information is obtained from NCBI Gene database)
Entrez gene ID7837
Official gene symbolPXDN
Full nameperoxidasin homolog (Drosophila)
Aliases,D2S448,D2S448E,KIAA0230,MG50,PRG2,PXN,VPO,
Gene summaryDrosophila peroxidasin is an extracellular matrix-associated peroxidase (Horikoshi et al., 1999 [PubMed 10441517]). It is expressed exclusively in hemocytes derived from head mesoderm at a very early stage of differentiation. Peroxidasin exists as a homotrimer with a unique hybrid structure that combines an enzymatically functional peroxidase domain with motifs that are typically found in extracellular matrix-associated proteins. It is a secreted protein that contains a secretory recognition sequence at its N terminus. Peroxidasin catalyzes hydrogen peroxide-driven radioiodination, oxidations, and the formation of dityrosine in vitro. It is also thought to function in extracellular matrix consolidation, phagocytosis, and defense.[supplied by OMIM]
LocationChromosome: 2   Locus: 2p25
Gene position1748291 - 1635659  Map Viewer
Gene orientationminus
Gene size112633 bp
Gene sequence
OMIM ID605158