Entrez gene ID | | 790 |
Official gene symbol | | CAD |
Full name | | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase |
Aliases | | ,-, |
Gene summary | | The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. [provided by RefSeq] |
Location | | Chromosome: 2 Locus: 2p22-p21 |
Gene position | | 27440258 - 27466654 Map Viewer |
Gene orientation | | plus |
Gene size | | 26397 bp |
Gene sequence |
| |
|