Entrez gene ID | | 800 |
Official gene symbol | | CALD1 |
Full name | | caldesmon 1 |
Aliases | | ,CDM,H-CAD,HCAD,L-CAD,LCAD,MGC21352,NAG22, |
Gene summary | | This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq] |
Location | | Chromosome: 7 Locus: 7q33 |
Gene position | | 134464164 - 134655480 Map Viewer |
Gene orientation | | plus |
Gene size | | 191317 bp |
Gene sequence |
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OMIM ID | | 114213 |
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